What Are The Effects of Material Mixing Uniformity on Tablet Production?

Quality aspect

-Uniformity of content: If mixed unevenly, it can lead to inconsistent content of active ingredients in the tablet. For example, in the production of drug containing tablets, the distribution of drug ingredients is uneven, and some tablets may have drug content exceeding the prescribed range, while others may be below the effective dose, which can affect the efficacy of the drug.

-Weight difference: Uneven mixing may result in significant differences in weight between different tablets. Due to the varying properties such as bulk density of materials, poor mixing can result in different filling conditions of each component in the tablet mold, leading to fluctuations in tablet weight.

In terms of production process

-Liquidity: Good mixing uniformity can make materials have good fluidity. Uniformly mixed materials are transported more smoothly to the tablet press, ensuring a stable feeding speed. Uneven materials may result in layering, agglomeration, and other issues, leading to decreased flowability of the material and subsequently affecting the continuity and efficiency of tablet pressing.

-Compressibility: The uniformity of mixing will affect the compressibility of the material. When the materials are mixed evenly, various components can be evenly distributed in the tablet, and can be better combined together during the compression process. If mixed unevenly, it may lead to uneven distribution of local pressure, causing problems such as cracking and loosening of the tablets.

Stability and appearance aspects

-Stability: Uniformly mixed materials help improve the stability of tablets. For example, for some components that are prone to moisture absorption or oxidation, only by evenly distributing them inside the tablet can they be better protected by other components, prevent local moisture absorption or oxidation, and extend the shelf life of the tablet.

-Appearance: Tablets made from materials with high uniformity have a more uniform color and appearance. If not mixed well, there may be spots and uneven color, which affects the appearance quality of the tablets.